Problem: A client has a prescription for insulin lispro to be injected subcutaneously three times a day. Given your knowledge of the onset of action of insulin lispro, when should you advise the client to inject this medication? A client has a prescription for insulin lispro to be injected subcutaneously three times a day. Given your knowledge of the onset of action of insulin lispro, when should you advise the client to inject this medication? 1 hour prior to bedtime 15 minutes before a meal 15 minutes after a meal 1 hour before a meal