Question: The nurse is preparing to administer the calcium channel blocker verapamil to a patient. The nurse knows which of the following are correct? Select all that apply. Adverse effect of edema of the ankles and feet secondary to vasodilation. Eliminated by kidneys and contraindicated in clients with decreased renal function. Grapefruit juice can inhibit the intestinal and hepatic metabolism of many drugs and, thus, raise their levels. Therapeutically used to treat angina pectoris, essential hypertension, and cardiac dysrhythmias.