Problem: Which step is essential when preparing and administering chemotherapeutic agents? Select all that apply. Know the potential side effects of the drugs being administered. Be prepared to take action if a reaction is suspected. And appropriate actions to ameliorate those effects. Have emergency drugs available. Have emergency equipment available. Know and follow agency's policies for administration of high-alert medications. Ensure patency of intravenous (IV) tubing by checking for blood return. Monitor surrounding tissue for damage. Ensure a nurse with a bachelor's degree or higher education administers the medication.