Pregnancy - Fungal Infections
Amphotericin B is the preferred treatment for deep fungal infections during pregnancy. Fluconazole is teratogenic in animals and a same pattern of craniofacial and cardiac anomalies has been reported in a few infants exposed to high doses of the drug during pregnancy. In rats, itraconazole, ketoconazole and voriconazole are teratogenic, and caspofungin is embryotoxic. None of these drugs should be used in pregnancy until there is a strong clinical indication for which no suitable alternative is available.