Discussion:
Predicting the inheritance of an X-linked trait
Mom Smith is heterozygous for an X-linked trait that can be recognized by a polymorphism when her DNA is cut with Hae III and probed with ExTend probe. The polymorphism is a 3.5kb band for normal and a 1.5kb band for disease. Please diagram what you predict the autoradiograph would look like for the above samples if the Smith sons 1 and 4 are affected and Smith Dad, Mom Jones and Dad Jones are not affected.
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1. Is the Smith daughter a carrier? Explain.
2. What if Dad Jones is also affected but not Mom Jones or Dad Smith?
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