Provide:
In the mutant hemoglobin known as HB Providence, an asparagine residue in the B-chain replaces Lys-82. In the normal hemoglobin, Lys-82 projects in the cental cavity of the hemoglobin molecule. Predict the effect of the Lys-Asn mutation of the affinity of allosteric modifiers (relative to normal Hb e.g HbA) and describe the effect the mutation would have on the function (oxygen binding) og HB Providence.
Any help would be greatly appreciated!