Possible ethical issues may limited clinical investigations


Problem: Evaluate research articles for how possible ethical issues may have limited clinical investigations. What ethical issues are pertinent specifically to healthcare research? How can these issues influence the research strategies chosen to investigate clinical topics?

References:

Reichow, B., Hume, K., Barton, E. E., & Boyd, B. A. (2018). Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD). The Cochrane database of systematic reviews, 5(5), CD009260.

Rodgers, M., Marshall, D., Simmonds, M., Le Couteur, A., Biswas, M., Wright, K., Rai, D., Palmer, S., Stewart, L., & Hodgson, R. (2020). Interventions based on early intensive applied behavior analysis for autistic children: a systematic review and cost-effectiveness analysis. Health technology assessment (Winchester, England), 24(35), 1-306.

Sandbank, M., Bottema-Beutel, K., Crowley, S., Cassidy, M., Dunham, K., Feldman, J. I., Crank, J., Albarran, S. A., Raj, S., Mahbub, P., & Woynaroski, T. G. (2020). Project AIM: Autism intervention meta-analysis for studies of young children. Psychological bulletin, 146(1)

Shi, B., Wu, W., Dai, M., Zeng, J., Luo, J., Cai, L., Wan, B., & Jing, J. (2021). Cognitive, Language, and Behavioral Outcomes in Children With Autism Spectrum Disorders Exposed to Early Comprehensive Treatment Models: A Meta-Analysis and Meta-Regression. Frontiers in psychiatry, 12, 691148.

 Su Maw, S., & Haga, C. (2018). Effectiveness of cognitive, developmental, and behavioral interventions for Autism Spectrum Disorder in preschool-aged children: A systematic review and meta-analysis. Heliyon, 4(9), e00763.

Tachibana, Y., Miyazaki, C., Ota, E., Mori, R., Hwang, Y., Kobayashi, E., Terasaka, A., Tang, J., & Kamio, Y. (2017). A systematic review and meta-analysis of comprehensive interventions for pre-school children with autism spectrum disorder (ASD). PloS one, 12(12), e0186502.

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