Problem: A 45-year-old man presents to his primary care physician complaining of increased hunger and thirst for the past month. Blood analysis reveals elevated glucose and hemoglobin A1c levels. His urine reveals ketone bodies. He is diagnosed with diabetes mellitus type 2. He is placed on an oral hypoglycemic agent that acts on intracellular nuclear receptors. Which of the following is most likely the prescribed agent? (A) Glipizide (B) Glucagon-like polypeptide 1 (C) Insulin (D) Metformin O(E) Pioglitazone