Problem:
Rewrite into 100 words, "Our primary objective is to quantify whether 8 weeks of treatment with rTMS will outperform medication in terms of improvement of depressive symptoms. We expect that rTMS is more effective than medication in reducing depressive symptoms in patients with TRD. Our secondary objective is to perform a health evaluation consisting of a cost-effectiveness analysis (CEA) with treatment response and remission as outcomes and a cost-utility analysis (CUA) with quality adjusted life years (QALYs) gained as outcome. The CEA and CUA will be performed along-side the trial. We expect rTMS to be more cost-effective than medication. Finally, we aim to perform exploratory analyses of the effect of rTMS on other symptoms associated with depression, compared to the effect of new medication on these symptoms. The symptoms consist of suicidality, anhedonia, anxiety, rumination, cognitive reactivity, and sleep. A second exploratory objective is to assess the effect of expectations regarding the treatment on its effectiveness.