Which of the following statements is true regarding origins of replication?
A. The number of active replication origins that are used during S phase can differ among cell types and during dissimilar developmental stages.
B. Replication of the genomes of diverse organisms like bacteria, archaea, yeast, Drosophila, mice and humans is initiated from the similar number of active replication origins.
C. The enzymes that mediate replication initiation recognize a specific DNA sequence in higher multi-cellular organisms like Drosophila, mice and humans.
D. Replication origins are licensed, activated and deactivated during S phase