MHC class I is a molecule involved in the immune system. In mice, class I MHC is derived from 2 (sometimes 3, but we will ignore that for now) loci- D and K, with several alleles possible at each loci- including d,b, and k. Expression of class I derived from these loci involves another molecule, β2m (beta-2-microglobulin) that is coded for at another locus. An inbred mouse that expresses Db and Kb is crossed with an inbred mouse that expresses no class I MHC. The F1 offspring are all DbKbKk.
7. What is the interaction of different alleles at the class I K locus?
8. What is the genotype of the parent not expressing any class I MHC (including class I MHC and β2m)?
9. What are the expected genotypes of the F2?
10. What are the expected phenotypes of the F2?
11. What are the ratios of the phenotypes in the F2?