Methotrexate-potent cancer chemotherapeutic agent
Methotrexate, a potent cancer chemotherapeutic agent, is a strong competitive inhibitor of the dihydrofolate reductase. Explain why this compound is an efficient inhibitor of the de novo synthesis of both purine and thymidine nucleotides.
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Though the enzyme Trypsin was capable to hydrolyze both TAME and BTEE substrates and I was wondering why? And why/ what makes chymotrypsin so much more precise??
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What does molecular weight of a protein encompass to do with the allergenic potential? This solution explains the relationship between the molecular weight of a protein and its potential to be an allergen.
Consider the isomerization reaction between glucose-6-phosphate and fructose-6-phosphate. a) Describe the ratio of fructose-6-phosphate to glucose-6-phosphate under standard conditions?
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Describe the ionization state (protonated or deprotonated) of each residue at pH5.2? Determine the pH optimum of lysozyme?
Biochemists usually like to study and characterize proteins as pure substances isolated from their native environment. Describe the single most important process or procedure which must be available prior to starting the purification of a protein?
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