Q1. Describe the impact of histone acetylation, phosphorylation and methylation on the gene transcription.
Q2. Name the inhibitors of histone methylation and deacetylation.
Q3. Explain the methods which can be used to detect the histone modifications.
Q4. Illustrate the goals of the global effort to recognize the human epigenome.
Discussion Assignment:
American Association for the Cancer Research Human Epigenome Task Force; European Union, Network of Excellence, Scientific Advisory Board, "Moving AHEAD with an International Human Epigenome Project," Nature, 454 (7205, August 7, 2008):711-15.
If you were to be a contributor to the AHEAD project, explain what your project would entail. Otherwise, how would you apply knowledge obtained from the AHEAD to your own research project?