Question: In which patients would The healthcare provider (HCP) be cautious to prescribe loperamide for diarrhea? Rationale: Loperamide is considered the first-line therapy for diarrhea control. However, there are warnings about the potential for loperamide to cause drowsiness (particularly patients who must stay alert). Because loperamide is an antimotility agent, it should be used with caution in patients with fever or bloody stools to avoid exacerbation of any type of infectious diarrhea. In addition, caution should be used in patients with liver failure. Page Number and Header: 532-534, First-Line Therapy Learning Objective: