In the anfinsen experiment refolding of rnase subsequent, Chemistry

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In the anfinsen experiment refolding of rnase subsequent

In the Anfinsen experiment refolding of RNase subsequent its denaturation with urea and beta-mercaptoethanol resulted in fully functional enzyme. conversely, denatured proteins do not always restart proper folding in vitro. Provide a possible scenario of why that may be?

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