Assignment:
Q1. a.) Identify all the functional groups present in lidocaine.
b.) Identify and draw the structures of two simpler compounds, one of which should be a carboxylic acid, from which you could make lidocaine. What type of reaction would these two compounds undergo in order to form lidocaine? What is the other product of this reaction?
Q2.) Oseltamivir, more popularly known as Tamiflu, is a drug used to treat influenza. It does so by binding to the active site of an enzyme called neuraminidase (found on the surface of the influenza virus).
(i) Identify, which atoms or functional groups could be involved in the binding of oseltamivir to the neuraminidase active site by:
- hydrogen bonding
- ionic interactions Only one example is required for each type of interaction.
(ii) What complementary functional group would need to be present in the neuraminidase active site for (a) hydrogen bonding and (b) ionic interactions to oseltamivir to be observed? You need only give one example of a functional group in the enzyme for each type of interaction.
Provide complete and step by step solution for the question and show calculations and use formulas.