Identifying all the genes affecting tooth development


Problem: You performed a genetic screen aimed at identifying all the genes affecting tooth development. One of the mutations results in the tooth canine tooth looking like a molar tooth. This phenotype is less severe in heterozygous animals than in homozygous animals (-/- > +/-). You also notice that the heterozygous animals show the same severity of phenotype as animals that are heterozygous but also carry have a duplication including an additional copy of the wild type gene (m/+ + --> one mutant copy of the gene and two wild type copies of the gene). Further, an equally severe phenotype is seen in animals that have the mutation uncovered by a deletion and the heterozygous animal (m/del).  summary = m/m > m/+ = m/deletion = m/+ +

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Biology: Identifying all the genes affecting tooth development
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