Problem: You have identified a new receptor tyrosine kinase (RTK) which you have designated XAX. XAX has sequence homology to the RTK MET, which has an important role in cancer. You are interested in studying whether XAX is a potentially valuable target against which to develop therapeutics for treatment of cancer patients.
a. Name two tests would you perform to determine which cancers XAX is likely to be relevant in, and what results of these tests would support the decision to pursue XAX.
b. Name two tests you would perform to determine if XAX had a functional role in promoting tumor growth, and what results would support XAX as a drug target.
c. Describe two approaches you would take to identify targeted drugs for XAX, and how you would perform preclinical tests of these drugs.