Problem: A 38-year-old woman with a past medical history significant for gastroesophageal reflux disease has been taking omeprazole (Prilosec) for 6 months without relief of symptoms. She has been treated appropriately for H. pylori with triple-drug regimen and confirmed eradicated of the infection and was previously treated for a year with ranitidine (Zantac). When considering an alternate course of treatment for GERD for this patient, which of the following is correct?
A. Omeprazole has demonstrated superior efficacy compared to esomeprazole.
B. It is likely that varying the dosage of one PPI will achieve comparable effectiveness to another PPI.
C. Better results have been achieved with on-demand dosing of esomeprazole compared to scheduled daily dosing.
D. Prescription PPIs have significantly superior efficacy compared to over-the-counter PPIs.