Problem:
Aldosterone is our major hormone for regulating sodium ion concentration in the blood. It is secreted by the outer later of the adrenal cortex and acts on receptors in the distal portion of the kidney tubules. When aldosterone bind to receptors it increases the ability for reabsorption of sodium ions by increasing transcription of sodium ATPase pumps and sodium ion channels. The ATPase pumps are inserted into the apical membrane to increase entry of sodium from the tubules and the pumps are inserted into the basal membrane to pump sodium ions out into the interstitial fluid and ultimately the blood.
Required:
Question: Explain the route through the organelles that the newly transcribed pump and channel mRNA will take from the nucleus to the insertion in the plasma membrane. Draw a diagram if you wish.
Question: Somehow the cell knows to transport the channel proteins to the apical surface and the pumps to the basal surface. How is this achieved?
Could someone explain this to me?