How to increase in the amount of glucokinase in liver
Consumption of a meal rich in carbohydrate or administration of insulin initiate an increase in the amount of glucokinase, phosphofructokinase-I and pyruvate kinase in liver. These changes reflect an increase in gene transcription resulting in an increased enzyme synthesis. High activity of these 3 enzymes favours the conversion of glucose to pyruvate, a characteristic of the well-fed state. When plasma insulin is low and glucagon is high, the gene transcription and synthesis of these key enzymes are decreased.