A G:C base-pair has one more hydrogen bond than an A:T base-pair.
• Suppose that one hydrogen bond contributes [ -0.616 ln(5) ]kcal/mole in standard free energy stabilization to a base-pair.
• Use the fact that RT = 0.616 when using natural logarithmsto the base e at 37ºC.
• Consider separately the two reactions A + T yields A:T andG + C yields G:C at 37ºC.
How many times larger will the equilibrium constant be for the G +C yields G:C reaction over the A + T yields A:T reaction.