Problem: A 54-year-old man taking morphine for uncontrolled severe low back pain is demonstrating loss of control (i.e., repeatedly running out early), compulsive use (i.e., repeated requests for higher opioid dose over other pain treatment options offered) and harm (i.e., oversedation). The patient's worrisome behavior is MOST suggestive of which of the following? Physical dependence Opioid Use Disorder (Addiction) Tolerance Opioid-induced hyperalgesia