Problem: Reduce this. In hypertensive patients, how does nurse-led education compared to standard care affect medication adherence over a six-month period? In this case, both a comparison group and a timeframe are included in the PICOT question. The comparison group (standard care) is essential for determining the effectiveness of the nurse-led education intervention. The six-month timeframe is chosen to provide a sufficient period for observing changes in medication adherence and to align with typical follow-up intervals in clinical practice.