Problem 1: You have made iPSCs from a mouse of the C57BL6 strain and are now injecting some of them into a skin fold on the back of a C57BL6 mouse. A teratoma forms that is about 20 mm3 in volume. You are also injecting the same number of cells into 129 mice and SCID mice. How do the teratomas differ?
Problem 2: After you have done that experiment, you also want to test iPSCs that you have made from fibroblasts harvested from your own skin. Which of the above mouse models would you choose and why?