Problem:
Question 1: If you were provided with a purified possible histone protein (from a bacterium), how would you establish if it is a DNA-binding protein?
Question 2: Assume that the protein binds DNA. How can you assess whether it is a site-specific or non-specific DNA-binding protein?
Question 3: How can you determine the binding affinity of the protein for the DNA?
I dont need long explanation. Just few sentences of expanation.