Question 1: How are CD4 + thymocytes that bear a T-cell receptor that interacts too strongly with an MHC class II-tissue-specific antigen peptide negatively selected?
a. When they interact too strongly with cTECs.
b. Dendritic cells in the thymic cortex engulf cTECs and present tissue-specific antigens via MHC class II.
c. When they interact too strongly with mTECs.
d. Dendritic cells in the thymic medulla engulf mTECs and present tissue-specific antigens via MHC class II.
e. When they interact too strongly either in the cortex or the medulla with TECs.
Question 2: Negative selection occurs when a majority of double-positive thymocytes with a proper T-cell receptor cannot interact with any MHC-peptide complexes presented within the thymus.
a. True
b. False