Formation of lactate and its consumption
Formation of lactate and its consumption: If anaerobic conctitions prevail, the reoxidation of NADH through the respiratory chain is prevented. Then the regeneration of NAD' from NADH is carried out by the action of lactate dehydrogenase on pyruvclte resulting in lactate and NAD' thereby allowing the glycolytic cycle to continue even in the absence of oxygen. Thus tissues that function under hypoxic conditions tend to produce lactate. The advantage of using pyruvate for reoxidation ofNADH lies in the fact that pyruvate iis the end product of glycnlysis and would readily be available in the cells.