Question 1)a) Draw the structure of following with numbering:
i) 1.3.7 - Trimethyl xanthene
ii) Pteridine
iii) 2-Benzyl thiazole
iv) 3-Methyl quinoline
v) 4-Propyl indole.
b) Write in brief electrophilic substitution reaction of five membered, Benzene fused heterocyclic ring system.
Question 2)a) What are diastereomers? Describe with appropriate examples.
b) Draw the Fischer projection of:
i) Meso 2.3-Dibromobutane
ii) 2-Chlorobutane
iii) 2R, 3S-2-Chlorobutanol.
c) What is racemic resolution ? Describe with appropriate examples the various methods used
Question 3) Answer the following:
a) Trans 1, 2-dimethyl cyclohexane is more stable than its C is isomer. Why?
b) Describe cyclohexane is more stable in chair form than boat form.
c) Explain:
i) Staggered and eclipsed
ii) Fischer projection formula.
d) Define the enantiomerism. Provide its pharmaceutical significance.
e) What are proteins? Explain its structure.
f) Give the advantage of Z/E nomenclature over cis and trans with example.
g) What are stereoselective and stereospecific reactions ? Give suitable examples.
Question 4) Answer the following:
a) Describe in brief conformation of n-butane.
b) Write a detailed note on Racemic modification.
c) Indicate more stable and least stable chair conformation of di-substituted cyclohexane.
d) What is combinatorial chemistry? Give the strategies used in Deconvolution method.
e) What are amino acids ? Explain different methods of synthesis of amino acid.
Question 5)a) Give the scheme of retrosynthesis of:
i) Propronolol
ii) Ciprofloxacin.
b) Explain in short in about:
i) Solid supported synthesis
ii) Thiazole synthesis.