Explain Ketoconazole
It is now seldom used. The other azoles have fewer adverse effects and are usually preferred. Ketoconazole remains an option for treatment of infections with dimorphic fungi (histoplasmosis, blastomycosis or coccidioidomycosis), but, as with itraconazole, is not recommended for treatment of meningitis because of these organisms because it does not cross the blood-brain barrier. Ketoconazole is also FDA-approved for treatment of paracoccidioidomycosis, candidiasis and severe cutaneous dermatophyte infections that do not respond to topical therapy.