Explain Adverse effects of Indinavir
In addition to adverse effects similar to those of other protease inhibitors, indinavir causes elevation of indirect bilirubin, indinavir-containing kidney stones and renal insufficiency, dermato- logic changes including alopecia, dry skin and mucous membranes, and paronychia and ingrown toenails. Patients should drink at least 1.5-2 liters of water daily to minimize renal adverse effects. Gallstones have also been reported.