Explain about the Toxicity of pyridoxine?
Though toxicity related to pyridoxine intake are rare, but use of high doses of pyridoxine for the treatment of pre-menstrual syndrome, carpal tunnel syndrome (compression of the median nerve at the wrist resulting in numbness, tingling, weakness in the hand and fingers), and some neurologic diseases has resulted in neurotoxicity. A upper limit (UL) of 100 mg/day as proposed by the United States Food and Nutrition Board has been adopted by the FAO/WHO 2004 Consultation on vitamin and mineral requirements.