Discuss the below:
Q: Explain Phase I Clinical Trials (in layman's terms) and explain the randomization and/or estimation implications for the phase. Please provide a specific example of this from the following journal article. Thank you.
Reference:
Harper, F. W., Heath, E. I., Gleason, M. E., Penner, L., LoRusso, P., Wang, D., & Albrecht, T. L. (2012). Physicians' Use of Patients' Daily Reports of Quality of Life to Evaluate Treatment Response in Phase I Cancer Trials. Journal of Cancer Therapy, 3, 582-588.