Question - A synthetic 20 amino acid polypeptide name Perrynova was designed as a small soluble molecule that would theoretically form stable β-sheet structures in the absence of disulfide bonds. NMR of Perrynova in solution indicates that it does, in fact, form a three-stranded antiparallel β sheet. Given the sequence of Perrynova below:
a) Draw a ribbon diagram for Perrynova indicating the likely residues for each hairpin turn between the β strands.
b) Show the interactions that are expected to stabilize this β-sheet structure
Perrynova sequence RGWSVQNGKYTNNGKTTEGR