Do we need a complex solution to lyse the cells, Biology

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Do we need a complex solution to lyse the cells

Problem:

I am trying to determine how quickly detergents act on bacterial cells (cell lysis). I would like to compare some detergents at difference concentrations for bacteriolytic activity. I don't care about all metabolites inside the cells (proteins, DNA, etcâ€¦). Many publications suggest that often more complicated solutions are used. My first thought was to use a simple prepared detergent in PBS or saline for lysing the cells. Do I need a complex solution to lyse the cells?

Could someone please give me a suggestion?

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