Question: A 56-year-old woman with chronic alcohol dependence has achieved periods of sobriety following residential treatment for up to a few months at a time. She attended 12 step groups regularly; however, these interventions have not been sufficient in keeping her from craving alcohol or from relapsing to alcohol when things get more stressful. You are considering a pharmacologic option to help her manage her alcohol use disorder. With consideration for efficacy, which of the following medications has the most evidence to support its use? A. Acamprosate B. Bupropion C. Fluoxetine D. Naltrexone