Discussion about the centromere of the x chromosome


Problem: A technique called FISH (fluorescence in situ hybridization) can be used to detect a specific DNA sequence.  In this method, A DNA sequence, such as a particular gene sequence, can be detected within an intact chromosome by using a DNA probe that is complementary to the sequence.  For example, let's consider the β-globin gene, which is found on human chromosome 11.  A probe complementary to the β-globin gene binds to that gene and shows up as a brightly colored spot on human chromosome 11.  In this way, researcher can detect where the β-globin gene is located within a set of chromosome.  Because the β-globin gene is unique and because human cells are diploid, a FISH experiment shows two bright spots per cell; the probe binds to each copy of chromosome 11. 

What would you expect to see if you used a probe complementary to a tandem array near the centromere of the X chromosome?

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Biology: Discussion about the centromere of the x chromosome
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