Problem:
A 55-year-old patient comes in with a severe acute episode of osteoarthritis. Patient is also overweight, a smoker, diagnosed with type 2 diabetes mellitus 7 years ago and has been on calcium-channel blockers to reduce blood pressure for more than a year. You notice that the drug order is for Celecoxib (Celebrex) 200mg once daily. You quickly run to your supervisor and suggest that the order should be modified for Aspirin 3g per day. Supervisor: Ok! But if we are going to administer Aspirin at this dosage for a while, we need to manage its toxicity. What other drug should we add to mitigate the main adverse effect of Aspirin? Question options: Antiemetic Serotonin Antagonist Proton Pump Inhibitor Anticoagulant Low dose Ibuprofen