Problem: For an unresponsive patient with suspected opioid overdose which of the following is the most reasonable treatment? If a patient has no pulse and no breathing, naloxone should be administered first before providing other care. With a patient in cardiac arrest, the focus should be high-quality CPR rather than naloxone administration. Administer 1 dose of naloxone and give 2 minutes of rescue breathing before considering CPR. Only administer naloxone if the patient is older than 12 years of age.