Discuss susceptibility of liver to injury by organic solvent


Problem: Assuming that some is working in the ABC Company at Birmingham, AL. One of the workers has incidentally ingested organic solvents. Your supervisor is concerned about liver injury. Why he/she (your supervisor) is concerned about susceptibility of liver to injury by that organic solvent? What is it?

A. Close proximity of gastrointestinal (GI) tract to liver

B. The liver is the primary site of chemical metabolism and the majority of the venous blood supply of GI tract goes directly to the liver

C. The vast majority of absorption of chemicals from the GI tract is from the intestine

D. The villi are lined with a layer of epithelial cells that separates the GI tract and the blood

E. Chemicals in GI tract will be present  for a longer period and this would tend to increase absorption of chemicals

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