Question: Which of the following statements about chronic and acute exposure and effects are correct? Want Online Help? Multiple select question. Acute exposure involves a single contact with a toxic chemical. It may last a few seconds or a few hours. Chronic exposure involves continuous or repeated contact with a toxic substance over a long period of time (months or years). Acute exposures, because they involve short contact with a toxic chemical, rarely have long-term effects. Chronic exposures are rarely life-threatening because the dosage in each exposure is generally very small. Need help? Review these concept resources. concept resources available.