Problem: Patients taking NSAIDs regularly should be taught to check with their healthcare provider or pharmacist before using additional OTC pain medications because of which of the following? Patients taking NSAIDs regularly should be taught to check with their healthcare provider or pharmacist before using additional OTC pain medications because of which of the following? there is a risk of Reye syndrome. no one should take more than one type of pain reliever at a time. increased GI upset could occur. many of the OTC preparations contain NSAIDs, and inadvertent toxicity could occur.