Discuss how the blood sugar level is maintained at a stable level in the well fed and fasting state
In the fed state, clearance of blood glucose is mainly by liver via glucokinase. Further, uptake of glucose also takes place in the extra-hepatic tissues (such as muscle, idipose tissue etc) favoured by insulin. These two mechanisms regulate the blood glucose level in the fed state. While in the fasting state, glucose release from the liver increases due to the action of glucagon and in the muscle by epinephrine.