Problem:
Bones adopt to stress by remodeling. Bone remodeling is the process of adding calcium, also known as deposition, to bone or releasing calcium, also called resorption, from bone into circulation. Muscles adapt to increasing levels of stress by increasing their function. Disuse leads to decreasing strength and muscle mass. Atrophy results in a decrease in both contractile and sarcoplasmic protein. The muscle fiber types do not atrophy at the same rate. Three main phases have been identified in the process of muscle regeneration; a destruction phase with the initial inflammatory response, a regeneration phase with activation and proliferation of satellite cells and a remodeling phase with maturation of the regenerated my fibers.