Question: What information should the nurse include when teaching a client with asthma being discharged with a prescription for prednisone? Select that all apply. Will have its therapeutic effect within 2 hours of administration. How to administer the daily intramuscular (IM) injection. If you miss a dose, wait until the next day and take both doses together. The medicine may interfere with sleep, so take the dose at the same time each morning. Prednisone is the same as prednisolone.