Problem: A 37-year-old man is diagnosed with Gram-positive bacteremia and started on Antibiotic X. The drug is administered intravenously and requires a plasma concentration of at least 20 mg/L to achieve therapeutic effects. Additional information regarding Antibiotic X's pharmacokinetics is listed below. Unfortunately, Antibiotic X can lead to severe side effects. As a result, the ordering physician wants to administer the lowest possible dose. Suppose the patient's body weight is 75 kg. Which of the following would be the smallest loading dose of Antibiotic X that can achieve therapeutic levels? Looking for Assignment Help? Pharmacokinetic Parameter Value Volume of distribution 0.4 L/kg Dosing interval 6 hours Bioavailability* 100% Elimination rate 2.6 L/h *For intravenous administration Elimination tool 600 mg 850 mg 450 mg 300 mg 1500 mg