Frequency response of a phosphorylation cycle:-
Consider the model of a covalent modification cycle as illustrated in Chapter 2 in which the kinase Z is not conserved, but it is produced and decays according to the reaction
Let u(t) be the input stimulus of the cycle and let X∗ be the output. Determine the frequency response of X∗ to u, determine its bandwidth, and make plots of it. What parameters can be used to tune the bandwidth?