Describe three ways in which enzyme activity levels in a cell can be regulated. Include at least one example inwhich the substrate itself is involved in regulation, and at leastone in which a non-substrate molecule is involved. For asubstrate/enzyme interaction, describe the induced fit model ofenzyme activity. For a non-substrate/enzyme interaction, describehow the enzyme itself is affected by that interaction. Finally,explain how negative feedback is often used to maintain metaboliccontrol of enzymatic pathways.