- Describe the mechanisms of action, biochemical targets and effects of these lipid-lowering drugs; statins, niacin, fibrates, colestipol, torcetrapib, avasimibe, implitapide, praluent and ezetimibe?
- What are SREBP and SCAP? What roles do they play in the cholesterol homeostasis?
- A nonfunctional MTP gene/protein causes ABL.What are the possible effects on lipid levels and cardiovascular pathology if this protein is overexpressed?
- Based on your understanding of the role of ABCA1 in the formation of HDL particles,how would you design a therapeutic modality to overcome a weakened interaction between ABCA1 and apoA-I that results from a mutation in ABCA1 gene?
How would you modulate the reverse cholesterol transport