Problem:
Question: The regions of DNA associated with the chromosome scaffold are known as SARS (scaffold associated regions). SARS DNA tends to be transcriptionally inactive. Which of the statements below explain why this is the case?
a) DNA not associated with histones tends to be trascriptionally inactive
b) DNA polymerase is unable to access DNA that is tightly compacted
c) opening the DNA so transcription factors could have access would result in destabilizing the chromosome structure
d) SARS DNA must be tightly compacted to protect the chromosomes against nucleases
Provide a brief explanation for your answer.